BDBM500975 4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4-yl)-7- ((4-methyl-6- ((3aS,6aS)-5- methylhcxahy dropyrrolo[3,4- b]pyrrol-1(2H)- yl)pyridin-2- yl)amino)-2,3- dihydro-1H- pyrrolo[3,4- c]pyridin-1-one::US11021481, Compound I-643::US11078201, Compound I-643::US11548890, Compound I-643

SMILES CN1C[C@@H]2CCN([C@@H]2C1)c1cc(C)cc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)n1

InChI Key InChIKey=XPERVLHCQRMJJE-HTAPYJJXSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500975   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500975(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4-yl)-7- ((...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500975(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4-yl)-7- ((...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500975(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4-yl)-7- ((...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500975(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4-yl)-7- ((...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500975(4-(1-methyl-1H- pyrrolo[2,3- b]pyridin-4-yl)-7- ((...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent