BDBM50097822 4-{(E)-4-[2-(4-tert-Butyl-phenyl)-6,6-dimethyl-cyclohex-1-enyl]-but-3-en-1-ynyl}-benzoic acid::CHEMBL424190

SMILES CC(C)(C)c1ccc(cc1)C1=C(\C=C\C#Cc2ccc(cc2)C(O)=O)C(C)(C)CCC1

InChI Key InChIKey=IQKSCFUBGQSAHR-YRNVUSSQSA-N

Data  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50097822   

TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50097822(4-{(E)-4-[2-(4-tert-Butyl-phenyl)-6,6-dimethyl-cyc...)
Affinity DataKd:  350nMAssay Description:Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50097822(4-{(E)-4-[2-(4-tert-Butyl-phenyl)-6,6-dimethyl-cyc...)
Affinity DataKd:  27nMAssay Description:Binding affinity towards retinoic acid receptor beta was determined using [3H]-ATRA (5 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50097822(4-{(E)-4-[2-(4-tert-Butyl-phenyl)-6,6-dimethyl-cyc...)
Affinity DataIC50:  25nMAssay Description:Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50097822(4-{(E)-4-[2-(4-tert-Butyl-phenyl)-6,6-dimethyl-cyc...)
Affinity DataIC50:  875nMAssay Description:Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50097822(4-{(E)-4-[2-(4-tert-Butyl-phenyl)-6,6-dimethyl-cyc...)
Affinity DataKd:  5nMAssay Description:Binding affinity towards retinoic acid receptor gamma was determined using [3H]-ATRA (5 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50097822(4-{(E)-4-[2-(4-tert-Butyl-phenyl)-6,6-dimethyl-cyc...)
Affinity DataIC50:  331nMAssay Description:Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed