BDBM50097980 CHEMBL169065::methyl 2-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)acetate::{4-[4-Amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-piperidin-1-yl}-acetic acid methyl ester

SMILES COC(=O)CN1CCC(CC1)n1cc(-c2cccc(OC)c2)c2c(N)ncnc12

InChI Key InChIKey=IQMVMHITWPJRIL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50097980   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(CHEMBL169065 | methyl 2-(4-(4-amino-5-(3-methoxyph...)
Affinity DataIC50:  84nMAssay Description:Inhibition of p60 c-Src tyrosine kinase enzyme activity in liquid-phase tyrosine phosphorylation assay at 830 ng/mLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(CHEMBL169065 | methyl 2-(4-(4-amino-5-(3-methoxyph...)
Affinity DataIC50:  1.47E+3nMAssay Description:Concentration required for inhibition of epidermal growth factor receptor (EGF-R) by tyrosine kinase enzyme activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(CHEMBL169065 | methyl 2-(4-(4-amino-5-(3-methoxyph...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of autophosphorylation of epidermal growth factor receptor (EGF-R) in a cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(CHEMBL169065 | methyl 2-(4-(4-amino-5-(3-methoxyph...)
Affinity DataIC50:  79.4nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Novartis Pharma Research

Curated by ChEMBL
LigandPNGBDBM50097980(CHEMBL169065 | methyl 2-(4-(4-amino-5-(3-methoxyph...)
Affinity DataIC50:  2.80E+3nMAssay Description:Concentration required for inhibition of c-Src mediated phosphorylation of Fak in IC8.1 fibroblast cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed