BDBM50098624 1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthene-9-carbonyl)-amino]-1-ethyl-piperidinium; iodide::CHEMBL34626

SMILES [I-].CC[N+]1(C\C2=C\CCCCCC2)CC[C@@H](CC1)NC(=O)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc12

InChI Key InChIKey=FOAFBMYSXIGAOX-CJCAHDPRSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50098624   

TargetC-C chemokine receptor type 1(Mus musculus)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  5.80nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable C-C chemokine receptor type 3(Mus musculus)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  350nMAssay Description:Inhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  6.10nMAssay Description:Inhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Mus musculus)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  21nMAssay Description:inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against Taer induced increase in intracellular [Ca2+] in KU812 cells expressing human CCR4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  0.730nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable C-C chemokine receptor type 3(Mus musculus)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  460nMAssay Description:Inhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Mus musculus)
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  5.80nMAssay Description:Inhibitory activity against 125 I -MIP-1 alpha binding to mouse CCR1 receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50:  0.580nMAssay Description:Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098624(1-Cyclooct-1-enylmethyl-4-[(2,7-dichloro-9H-xanthe...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity in human CCR2b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed