BDBM50099963 CHEMBL30432::N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine

SMILES CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1

InChI Key InChIKey=DYYZXRCFCVDSKD-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50099963   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  97nMAssay Description:Inhibition of erbB2 overexpressing HB4a.e5.2 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 9(Homo sapiens (Human))
Universidad De Talca

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  5.01E+4nMAssay Description:Inhibition of human TASK3 expressed in HEK293 cells by Ti+ flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  1nMAssay Description:Inhibition of EGF receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50: >8.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  7nMAssay Description:Inhibition of EGFR intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELVAK...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  16nMAssay Description:Inhibition of ErbB-2 intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELV...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of erbB2 overexpressing BT 474 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rattus norvegicus)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  390nMAssay Description:Inhibition of erbB2 overexpressing Calu3 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  210nMAssay Description:Inhibition of EGF receptor overexpressing HN5 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  70nMAssay Description:Inhibition of erbB2 overexpressing BT 474 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rattus norvegicus)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  390nMAssay Description:Inhibition of erbB2 overexpressing Calu3 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Affinity DataIC50:  20nMAssay Description:Inhibition of erbB4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed