BDBM50100294 2-(2-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL22235

SMILES Clc1ccccc1Oc1cc(Cn2ccnc2)ccc1C#N

InChI Key InChIKey=KJSMLERTEOUXOK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50100294   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100294(2-(2-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Affinity DataIC50:  41nMAssay Description:Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100294(2-(2-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed