BDBM50101222 2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indol-5-yl}-N,N-diisobutyl-isobutyramide::CHEMBL298366

SMILES CC(C)CN(CC(C)C)C(=O)C(C)(C)c1ccc2[nH]c(c(CCNCCCCc3cccnc3)c2c1)-c1cc(C)cc(C)c1

InChI Key InChIKey=MLPMAZIIWKKUHO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50101222   

TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101222(2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-bu...)
Affinity DataIC50:  400nMAssay Description:Inhibition of GnRH-stimulated luteinizing hormone (LH) release in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101222(2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-bu...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of GnRH-stimulated phosphatidyinositol (PI) hydrolysis in cloned chinese hamster ovary (CHO) cells expressing human GnRH receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101222(2-{2-(3,5-Dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-bu...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GnRH-stimulated phosphatidyinositol (PI) hydrolysis in cloned chinese hamster ovary (CHO) cells expressing human GnRH receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed