BDBM50101813 CHEBI:31399::Cilnidipine

SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC\C=C\c1ccccc1

InChI Key InChIKey=KJEBULYHNRNJTE-DHZHZOJOSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50101813   

TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  1.27E+4nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity against N-type calcium channel by calcium influx into IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Voltage-dependent L-type calcium channel in rat thoracic aorta ringMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human N type calcium channel Cav2.2 endogenously expressed in SH-SY5Y cells assessed as calcium influx by FRIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of human T type calcium channel Cav3.2 expressed in HEK-293T cells assessed as calcium influx by FRIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in rat thoracic aorta ring assessed as effect on high K+ induced contraction by Magnus methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed