BDBM50104435 4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl ester::CHEMBL87563

SMILES CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1

InChI Key InChIKey=YKGYIDJEEQRWQH-UHFFFAOYSA-N

Data  3 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50104435   

TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataKi:  1.90E+3nMAssay Description:Competitive inhibition of human plasmin assessed as reduction in hydrolytic activity using S-2251 as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataKi:  2.92E+3nMAssay Description:Inhibition of human factor 12a using chromogenic substrate by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
University Of Technology

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibitory activity of the compound against porcine kidney amine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  383nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  687nMAssay Description:Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-pNA-HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  4.61E+3nMAssay Description:Inhibition of purified human factor 10a using Suc-Ile-Glu(gammaPip)-GlyArg-pNa-HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of human plasma kallikrein using D-Pro-Phe-Arg-pNA-2HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  431nMAssay Description:Inhibition of human uPA using pyro-Glu-Gly-Arg-pNA as substrate assessed as para-nitroaniline release from substrate measured for 5 mins by spectroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  1.54E+4nMAssay Description:Inhibition of recombinant human tPA using H-D-Ile-Pro-L-Arg-pNA-2HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-pNA-HCl as substrate measured for 5 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed