BDBM50106864 (1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(4-methylpiperazin-1-yl)methanone::CHEMBL105592::[1-(3-Benzo[1,3]dioxol-5-ylmethyl-3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-(4-methyl-piperazin-1-yl)-methanone

SMILES CN1CCN(CC1)C(=O)c1cn(Cc2cncn2Cc2ccc3OCOc3c2)cc1-c1cccc2ccccc12

InChI Key InChIKey=HWLBLFBLGGVDBT-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50106864   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Lg Life Sciences R & D Center

Curated by ChEMBL
LigandPNGBDBM50106864((1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazo...)
Affinity DataKi:  80nMAssay Description:Reversible inhibition of human CYP3A4 in liver microsomes by Dixon and Cornish-Bowden plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106864((1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazo...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of farnesyltransferase activity against K-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lg Life Sciences R & D Center

Curated by ChEMBL
LigandPNGBDBM50106864((1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazo...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human CYP3A4 in liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106864((1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazo...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of farnesyltransferase activity against H-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106864((1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazo...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed