BDBM50107249 1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-ethyl]-4-pyridin-2-yl-piperazine::CHEMBL423181

SMILES COc1ccc2CCC(CCN3CCN(CC3)c3ccccn3)Cc2c1

InChI Key InChIKey=MQYILSGYILZXMS-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50107249   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute And Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107249(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  0.160nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50107249(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  0.160nMAssay Description:Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50107249(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataKi:  1.73E+3nMAssay Description:Binding affinity towards dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute And Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107249(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Karolinska Institute And Karolinska University Hospital

Curated by ChEMBL
LigandPNGBDBM50107249(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed