BDBM50108052 1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxybenzene::CHEMBL46909::trans-2,4,3',5'-tetramethoxystilbene

SMILES COc1ccc(\C=C\c2cc(OC)cc(OC)c2)c(OC)c1

InChI Key InChIKey=JDBCWSHYEQUBLW-AATRIKPKSA-N

Data  1 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50108052   

TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataKi:  3nMAssay Description:Inhibition of human CYP1B1 using ethoxyresorufin as substrate preincubated for 3 mins followed by NADPH addition measured after 10 mins by EROD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant human CYP1A2 using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Chulalongkorn University

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5aplha cells assessed as O-deethylation of ethoxyresorufin in presence of NADP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli DH5alpha using ethoxyresorufin as substrate preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5alpha using ethoxyresorufin as substrate preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in Escherichia coli DH5alpha using ethoxyresorufin as substrate preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli membranes co-expressing NADPH-P450 reductase assessed as reduction in ethoxyreso...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  300nMAssay Description:Inhibition of CYP1A1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of recombinant human CYP1B1 using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  209nMAssay Description:Inhibition of recombinant human CYP1A1 using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  300nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes epressing human cytochrome P450 1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM50108052(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed