BDBM50109109 (R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarbamoyl)benzyl)butanoic acid::(R)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-benzyl]-butyric acid::CHEMBL115604

SMILES CC[C@H](Cc1ccc(OC)c(c1)C(=O)NCc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key InChIKey=YSFRXMSOTXOZQZ-OAHLLOKOSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50109109   

TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataEC50:  1.50E+3nMAssay Description:Compound was tested for half maximum transactivation activity of human peroxisome proliferator-activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50: >5.00E+4nMAssay Description:Binding affinity of compound to human peroxisome proliferator-activated receptor gamma was determined by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataEC50:  2.40E+4nMAssay Description:Binding affinity of compound to human peroxisome proliferator-activated receptor alpha was determined by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50:  3.78E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50:  3.42E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataEC50: >1.50E+4nMAssay Description:Compound was tested for half maximum transactivation activity of human peroxisome proliferator-activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed