BDBM50111386 CHEMBL3604792

SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCNCC1

InChI Key InChIKey=VAMWJMVATUYTLB-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50111386   

TargetRibosomal protein S6 kinase alpha-3(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111386(CHEMBL3604792)
Affinity DataEC50:  140nMAssay Description:Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111386(CHEMBL3604792)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed