BDBM50114716 CHEMBL329263::N-[2-(2-Benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-acetamide

SMILES COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1

InChI Key InChIKey=URBHHEGXYAFBNW-UHFFFAOYSA-N

Data  6 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50114716   

TargetMelatonin receptor type 1B(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]-iodomelatonin as rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Institut De Chimie Pharmaceutique Albert Lespagnol

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataKi:  1.27nMAssay Description:Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]-iodomelatonin as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Institut De Chimie Pharmaceutique Albert Lespagnol

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Institut De Chimie Pharmaceutique Albert Lespagnol

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Institut De Chimie Pharmaceutique Albert Lespagnol

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataIC50:  0.0158nMAssay Description:Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]-GTP-gammaS, binding in Chinese hamster ovarian (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Institut De Chimie Pharmaceutique Albert Lespagnol

Curated by ChEMBL
LigandPNGBDBM50114716(CHEMBL329263 | N-[2-(2-Benzyl-5-methoxy-benzofuran...)
Affinity DataEC50:  21nMAssay Description:Intrinsic activity evaluated on [35S]-GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed