BDBM50118688 4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-thiophene-2-carbonitrile::CHEMBL139749

SMILES CC1(C)OC(=O)Nc2ccc(cc12)-c1csc(c1)C#N

InChI Key InChIKey=OTDVEVBRJYVJHY-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50118688   

TargetProgesterone receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118688(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  6.70nMAssay Description:Antagonist activity against progesterone receptor (PR) in an assay using PRE-luciferase plasmid co-transfected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118688(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  280nMAssay Description:Antagonist activity against the Androgen Receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118688(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  1.86E+3nMAssay Description:Antagonist activity against the Glucocorticoid Receptor (GR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118688(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  6.70nMAssay Description:Antagonist activity against the Progesterone Receptor (PR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118688(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataEC50:  61.1nMAssay Description:Agonist activity against progesterone receptor (PR) in an alkaline phosphatase assay in the T47D human breast carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118688(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  1.39E+3nMAssay Description:Antagonist activity against the Mineralocorticoid Receptor (MR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed