BDBM50119 1-(3-chlorophenyl)-6-(2-furanyl)-3-methyl-4-pyrazolo[3,4-b]pyridinecarboxylic acid::1-(3-chlorophenyl)-6-(2-furyl)-3-methyl-pyrazolo[3,4-b]pyridine-4-carboxylic acid::1-(3-chlorophenyl)-6-(furan-2-yl)-3-methyl-pyrazolo[3,4-b]pyridine-4-carboxylic acid::1-(3-chlorophenyl)-6-(furan-2-yl)-3-methylpyrazolo[3,4-b]pyridine-4-carboxylic acid::MLS000564133::SMR000151728::US9394303, 1::cid_4178486

SMILES Cc1nn(-c2cccc(Cl)c2)c2nc(cc(C(O)=O)c12)-c1ccco1

InChI Key InChIKey=YABKWSWWULJVQN-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50119   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50119(1-(3-chlorophenyl)-6-(2-furanyl)-3-methyl-4-pyrazo...)
Affinity DataKi:  2.64E+3nM ΔG°:  -7.60kcal/mole IC50:  1.37E+4nMpH: 7.4 T: 2°CAssay Description:Sensitive and quantitative FP-based binding assays were developed and optimized to determine the binding affinities of small-molecule inhibitors to t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50119(1-(3-chlorophenyl)-6-(2-furanyl)-3-methyl-4-pyrazo...)
Affinity DataIC50:  9.55E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay