BDBM50119260 CHEMBL100559::N-(2-Hydroxy-5-oxo-tetrahydro-furan-3-yl)-2-[2-(5-trifluoromethanesulfonylamino-naphthalen-1-yloxy)-acetylamino]-butyramide

SMILES CC(C)C(NC(=O)COc1cccc2c(NS(=O)(=O)C(F)(F)F)cccc12)C(=O)N[C@H]1CC(=O)OC1O

InChI Key InChIKey=WLZOCGMSLPOOIC-ULUNDTCASA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50119260   

TargetCaspase-1(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119260(CHEMBL100559 | N-(2-Hydroxy-5-oxo-tetrahydro-furan...)
Affinity DataIC50:  127nMAssay Description:Inhibition of Caspase-1 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119260(CHEMBL100559 | N-(2-Hydroxy-5-oxo-tetrahydro-furan...)
Affinity DataIC50:  615nMAssay Description:Inhibition of Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119260(CHEMBL100559 | N-(2-Hydroxy-5-oxo-tetrahydro-furan...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of Caspase-7 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119260(CHEMBL100559 | N-(2-Hydroxy-5-oxo-tetrahydro-furan...)
Affinity DataIC50:  207nMAssay Description:Inhibition of Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119260(CHEMBL100559 | N-(2-Hydroxy-5-oxo-tetrahydro-furan...)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed