BDBM50120423 CHEMBL3617971::US9290459, 1A::US9670166, 1A
SMILES FC(F)(F)c1cccc(c1)N1C2=C([C@H](NC1=O)c1ccc(cc1)C#N)C(=O)CC2
InChI Key InChIKey=IOAQHJLFLCALPO-LJQANCHMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50120423
Affinity DataEC50: 22nMpH: 7.5Assay Description:Various concentrations of the neutrophil elastase inhibitor are incubated with plasma. Subsequently, the enzyme activity is measured using the fluoro...More data for this Ligand-Target Pair
Affinity DataIC50: 11.5nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMT: 2°CAssay Description:The inhibition of cytochrome P450 2C9-isoenzyme catalysed hydroxylation of Diclofenac by the test compound is assayed at 37° C. with human liver ...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMT: 2°CAssay Description:The inhibition of cytochrome P450 2C19-isoenzyme catalysed hydroxylation of Mephenytoin by the test compound is assayed at 37° C. with human live...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMT: 2°CAssay Description:The inhibition of cytochrome P450 2C8-isoenzyme catalysed deethylation of Amodiaquine by the test compound is assayed at 37° C. with human liver ...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of neutrophil elastase in human plasma using MeOSuc-Ala-Ala-Pro-Val-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair