BDBM50121205 CHEBI:18295::Histamine

SMILES NCCc1c[nH]cn1

InChI Key InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N

Data  57 KI  2 IC50  7 Kd  50 EC50

PDB links: 34 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121205   

TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells incubated for 40 min by liquid scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]NAMH from human H3R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataEC50:  2.5nMAssay Description:Agonist activity at human H3R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human H3R expressed on SK-N-MC cells assessed as inhibition of forskolin-induced beta galactosidase activity preincubated with fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50121205(CHEBI:18295 | Histamine)
Affinity DataEC50:  63nMAssay Description:Agonist activity at human H3R expressed on HEK293T cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed