BDBM50121210 CHEMBL3622374

SMILES Nc1ccccc1NC(=O)c1ccc(cc1)-c1cn(CCc2ccsc2)nn1

InChI Key InChIKey=LBLSLSOENGWIHL-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50121210   

TargetHistone deacetylase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC5 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC4 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC8 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  240nMAssay Description:Inhibition of HDAC3 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of HDAC1 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human KDAC8 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human KDAC6 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  3.94E+3nMAssay Description:Inhibition of human KDAC3 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of human KDAC1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Schistosoma mansoni)
Washington University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC (unknown origin) using Fluoro-Substrate Peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of recombinant human full length C-terminal GST-tagged HDAC1 expressed in baculovirus Sf9 insect cells using HDAC Glo I/II substrate by Ki...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  240nMAssay Description:Inhibition of recombinant human HDAC3/GST-tagged NCOR1 DAD (397 to 503 residues) expressed in baculovirus expression system using Fluor de Lys as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC8 (unknown origin) using Fluoro-Substrate Peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human full length C-terminal GST-tagged HDAC4 (627 to end residues) expressed in baculovirus Sf9 insect cells using HDAC cl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human His-tagged HDAC6 expressed in insect cells using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human recombinant full-length C-terminal GST-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  240nMAssay Description:Inhibition of human recombinant HDAC3/GST-tagged NCOR1 DAD (397 to 503 residues) expressed in baculovirus expression system by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >19nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  240nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC6 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed