BDBM50121710 2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,3-dione::CHEMBL88645::PIQ-22

SMILES CCc1cccc(CC)c1-n1c(O)cc2ccccc2c1=O

InChI Key InChIKey=CQTGQCXLVRVXLV-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50121710   

TargetAminopeptidase N(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50121710(2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,3-dione |...)
Affinity DataKi:  120nMAssay Description:Inhibition of APN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50121710(2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,3-dione |...)
Affinity DataIC50:  409nMAssay Description:Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121710(2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,3-dione |...)
Affinity DataIC50: >3.40E+5nMAssay Description:Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPuromycin-sensitive aminopeptidase(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121710(2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,3-dione |...)
Affinity DataIC50:  7.80E+3nMAssay Description:Puromycin sensitive aminopeptidase inhibitory activity of the compound was determined by the use of L-Ala AMC with MOLT-4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed