BDBM50123052 2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxolane]-8-ylsulfonyl}-4-hydroxyphenoxy)-3,5-dichlorophenyl]-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione::2-{3,5-dichloro-4-[4-hydroxy-3-spiro[8-azabicyclo[3.2.1]octane-3,2'-(tetrahydrofuran)]-8-ylsulfonylphenoxy]phenyl}-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione::CHEMBL125946

SMILES Oc1ccc(Oc2c(Cl)cc(cc2Cl)-n2ncc(=O)[nH]c2=O)cc1S(=O)(=O)N1C2CCC1CC1(CCCO1)C2

InChI Key InChIKey=JHJHCOACTCIKNP-UHFFFAOYSA-N

Data  1 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50123052   

TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataKi:  0.280nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataIC50:  0.776nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataEC50:  62nMAssay Description:Effective concentration of the compound binding towards TRbeta1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataEC50:  1.50E+3nMAssay Description:Effective concentration of the compound binding towards TRalpha in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed