BDBM50123163 CHEMBL3622672::US9388160, 12

SMILES COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1NC(=O)\C=C\CN1CCCCC1

InChI Key InChIKey=NAVGIMRWOWYNEP-DHZHZOJOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50123163   

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Teligene

US Patent
LigandPNGBDBM50123163(CHEMBL3622672 | US9388160, 12)
Affinity DataIC50:  22nMpH: 7.4 T: 2°CAssay Description:The assay was performed using Kinase-Glo Plus luminescence kinase assay kit (Promega). The compounds were diluted in 10% DMSO and 5 μl of the dilu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Qilu Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50123163(CHEMBL3622672 | US9388160, 12)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of EGFR (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Homo sapiens (Human))
Teligene

US Patent
LigandPNGBDBM50123163(CHEMBL3622672 | US9388160, 12)
Affinity DataIC50: <100nMpH: 7.4 T: 2°CAssay Description:The assay was performed using Kinase-Glo Plus luminescence kinase assay kit (Promega). The compounds were diluted in 10% DMSO and 5 μl of the dilu...More data for this Ligand-Target Pair
In DepthDetails US Patent