BDBM50124603 5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL8007

SMILES CC1=CC(C)(C)Nc2ccc-3c(C(CC=C)Oc4cccc(Cl)c-34)c12

InChI Key InChIKey=UXGUYYJUKZKENF-UHFFFAOYSA-N

Data  2 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50124603   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124603(5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]-Dexamethasone as radioligand in SF-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124603(5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]-progesterone from human Progesterone receptor AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124603(5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of conconavalin A stimulated rat splenocyte proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124603(5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6...)
Affinity DataEC50:  45nMAssay Description:Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]-Dexamethasone as radioligand in SF-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124603(5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6...)
Affinity DataEC50:  440nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed