BDBM50124931 5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one::CHEMBL352207

SMILES Clc1ccc(CN2CCN(CC2)C2CCc3cccc4CCN(c34)C2=O)cc1

InChI Key InChIKey=MDCLDPYRUQCBTL-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50124931   

TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124931(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  3nMAssay Description:D4 receptor functional activity was measured inhibition of quinpirole stimulated [35S]GTP-gamma-S binding from cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124931(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124931(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  62nMAssay Description:D2 receptor functional activity was measured through reversal of quinpirole inhibited, forskolin stimulated cAMP production from whole cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124931(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]-YM 09151 from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124931(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  2.28E+3nMAssay Description:Displacement of [3H]-YM 09151 from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed