BDBM50125628 3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5-methoxy-5-methyl-5H-furan-2-one::CHEMBL18498

SMILES COC1(C)OC(=O)C(=C1c1ccc(cc1)S(C)(=O)=O)c1ccc(F)cc1

InChI Key InChIKey=PBJWWPFSOCFQEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50125628   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50125628(3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50125628(3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50:  69nMAssay Description:Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50125628(3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in the sensitive U937 microsome assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50125628(3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration of the compound was measured against Cyclooxygenase-2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed