BDBM50126158 3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-5'-yl)benzonitrile::CHEMBL28157

SMILES Fc1cc(cc(c1)-c1ccc2NC(=S)C3(CCCCC3)c2c1)C#N

InChI Key InChIKey=HJOUYAMEBCDGKK-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50126158   

TargetAndrogen receptor(Mus musculus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against Androgen receptor in mouse fibroblast L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against glucocorticoid receptor in human lung A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataIC50:  16nMAssay Description:Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Mus musculus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against Androgen receptor in mouse fibroblast L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against glucocorticoid receptor in human lung A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataIC50:  7.43nMAssay Description:Inhibitory progestational activity on oral administration in uterine C3 modelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50126158(3-fluoro-5-(2'-thioxo-1',2'-dihydrospiro[cyclohexa...)
Affinity DataEC50:  0.360nMAssay Description:Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed