BDBM50127315 6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::A-315493::CHEMBL43631

SMILES Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12

InChI Key InChIKey=ACXPVQQIYOUAGF-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50127315   

TargetGeranylgeranyl transferase type-1 subunit beta(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127315(6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H...)
Affinity DataIC50:  24nMAssay Description:Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50127315(6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50127315(6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H...)
Affinity DataEC50:  5.90nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50127315(6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H...)
Affinity DataIC50:  0.730nMAssay Description:In vitro inhibitory activity against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed