BDBM50127708 (1H)-indole-3-carbonitrile::1H-Indole-3-carbonitrile::CHEMBL46724

SMILES N#Cc1c[nH]c2ccccc12

InChI Key InChIKey=CHIFTAQVXHNVRW-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50127708   

TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50127708((1H)-indole-3-carbonitrile | 1H-Indole-3-carbonitr...)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50127708((1H)-indole-3-carbonitrile | 1H-Indole-3-carbonitr...)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1/2(Homo sapiens (Human))
Roche Discovery Welwyn

Curated by ChEMBL
LigandPNGBDBM50127708((1H)-indole-3-carbonitrile | 1H-Indole-3-carbonitr...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibitory activity against (IMPDH) inosine 5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50127708((1H)-indole-3-carbonitrile | 1H-Indole-3-carbonitr...)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed