BDBM50128544 (10R,13S)-17-Benzoimidazol-1-yl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15-dodecahydro-cyclopenta[a]phenanthren-3-one::CHEMBL77789

SMILES C[C@]12CCC3C(CCC4=CC(=O)CC[C@]34C)C1CC=C2n1cnc2ccccc12

InChI Key InChIKey=JPMBLPVHJHQFHR-OSTLVTSRSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50128544   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128544((10R,13S)-17-Benzoimidazol-1-yl-10,13-dimethyl-1,2...)
Affinity DataIC50:  915nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50128544((10R,13S)-17-Benzoimidazol-1-yl-10,13-dimethyl-1,2...)
Affinity DataIC50:  770nMAssay Description:Inhibition of [1-beta-3H]-androstenedione binding to human steroid 5-alpha-reductase type I expressed in DU-145 cells at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128544((10R,13S)-17-Benzoimidazol-1-yl-10,13-dimethyl-1,2...)
Affinity DataIC50:  915nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 17 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50128544((10R,13S)-17-Benzoimidazol-1-yl-10,13-dimethyl-1,2...)
Affinity DataIC50:  480nMAssay Description:Inhibition of [1-beta-2beta-3H]- -testosterone binding to human steroid 5-alpha-reductase type 2 of BPH tissue at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed