BDBM50129145 9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-enylidene)-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL65690

SMILES [#6]\[#6](-[#6])=[#6]\[#6]=[#6]-1/[#8]-c2ccc(F)cc2-c2ccc3-[#7]C([#6])([#6])[#6]=[#6](-[#6])-c3c-12

InChI Key InChIKey=VRWXHHASXOUVMH-FBHDLOMBSA-N

Data  1 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50129145   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for human progesterone receptor; Not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against human Estrogen receptor; not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity against Androgen receptor; not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataEC50:  1.70nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataIC50:  177nMAssay Description:Antagonist activity at glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at mineralocorticoid receptor (hMR); not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed