BDBM50132679 CHEMBL111128::Methyl-((2S,3S)-3-naphthalen-2-yl-bicyclo[2.2.1]hept-2-ylmethyl)-amine

SMILES CNC[C@H]1C2CCC(C2)[C@@H]1c1ccc2ccccc2c1

InChI Key InChIKey=PORDAYLSLHLTRQ-FYOYPEGLSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50132679   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataKi:  99nMAssay Description:Compound was tested for its ability to displace [3H]-citalopram from norepinephrin transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataIC50:  9nMAssay Description:Inhibition of SERT (unknown origin) assessed as reduction of [3H]5-HT re-uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataIC50:  28nMAssay Description:Inhibition of NET (unknown origin) assessed as reduction of [3H]-NE re-uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataIC50:  96nMAssay Description:Inhibition of DAT (unknown origin) assessed as reduction of [3H]-DA re-uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataIC50:  86nMAssay Description:Displacement of [3H]-Nisoxetine from norepinephrin transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibition of [3H]-NE re-uptake into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132679(CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...)
Affinity DataIC50:  9nMAssay Description:In vitro ability of compound to inhibit 5-HT re-uptake of radiolabelled [3H]-tritium trasmitter into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed