BDBM50134771 CHEMBL3754515

SMILES Nc1ccc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1

InChI Key InChIKey=KHPCIHZXOGHCLY-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50134771   

LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  15nMAssay Description:Inhibition of TNIK (unknown origin) in presence of ATP (Km)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  134nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  160nMAssay Description:Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of phosphorylation of traf2 at ser/thr residue by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human ERG transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  160nMAssay Description:Inhibition of MAP4K4 in human GripTite 293 MSR cells assessed as reduction in TRAF2 Ser/Thr phosphorylation incubated for 1.5 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMisshapen-like kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50:  8nMAssay Description:Inhibition of MINK (unknown origin) in presence of ATP (Km)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed