BDBM50137720 (1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(pyrazine-2-carbonyl)-amino]-butyrylamino}-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (1-cyclopropylaminooxalyl-butyl)-amide::(1S,5S,6R)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(pyrazine-2-carbonyl)-amino]-butyrylamino}-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (1-cyclopropylaminooxalyl-butyl)-amide::CHEMBL264623

SMILES CCCC(NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C(C)C)C(C)C)C(=O)C(=O)NC1CC1

InChI Key InChIKey=RJUXWBNDZWRQEF-YOAIMQRKSA-N

Data  7 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50137720   

TargetCathepsin B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity of the compound against cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  120nMAssay Description:Binding affinity of the compound towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  123nMAssay Description:Cytotoxic activity in rat liver Huh-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  123nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  583nMAssay Description:Inhibitory activity of the compound against ChymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  683nMAssay Description:Inhibitory activity of the compound against cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity of the compound against Protease using replicon assay in rats at 25 microM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Cytotoxic activity in rat liver Huh-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibitory activity of the compound against Protease using replicon assay in rats at 25 microM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataIC50:  7.00E+3nMAssay Description:Cytotoxic activity in rat liver Huh-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibitory activity of the compound against Protease using replicon assay in rats at 25 microM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed