BDBM50138599 CHEMBL154751::N-(2,6-Dimethyl-phenyl)-2-{4-[(R)-2-hydroxy-3-(2-methyl-benzothiazol-5-yloxy)-propyl]-piperazin-1-yl}-acetamide

SMILES Cc1nc2cc(OC[C@H](O)CN3CCN(CC(=O)Nc4c(C)cccc4C)CC3)ccc2s1

InChI Key InChIKey=YZXYDKIBYWKPNU-HXUWFJFHSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50138599   

TargetCytochrome P450 2C9(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50138599(CHEMBL154751 | N-(2,6-Dimethyl-phenyl)-2-{4-[(R)-2...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cytochrome P450 2C9 of isolated guinea pig heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisomal acyl-coenzyme A oxidase 1(Rattus norvegicus)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50138599(CHEMBL154751 | N-(2,6-Dimethyl-phenyl)-2-{4-[(R)-2...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against Palmitoyl-CoA oxidase to inhibit rat heart mitochondrial Palmitoyl-CoA oxidation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisomal acyl-coenzyme A oxidase 1(Rattus norvegicus)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50138599(CHEMBL154751 | N-(2,6-Dimethyl-phenyl)-2-{4-[(R)-2...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of palmitoyl-CoA oxidation in rat heart mitochondriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50138599(CHEMBL154751 | N-(2,6-Dimethyl-phenyl)-2-{4-[(R)-2...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of cytochrome P450 3A4 of isolated guinea pig heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50138599(CHEMBL154751 | N-(2,6-Dimethyl-phenyl)-2-{4-[(R)-2...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cytochrome P450 1A2 of isolated guinea pig heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed