BDBM50140255 CHEMBL3754085

SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1nc(ccc1C)-c1cccc(CO)c1

InChI Key InChIKey=WRBLOVAXQYYLFM-UHFFFAOYSA-N

Data  3 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50140255   

TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataKi: >1.40E+4nMAssay Description:Binding affinity to human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataKi: >1.75E+4nMAssay Description:Binding affinity to human EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataKi: >1.89E+4nMAssay Description:Binding affinity to human EP2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50:  39nMAssay Description:Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50:  39nMAssay Description:Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >2.50E+4nMAssay Description:Binding affinity to human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >2.50E+4nMAssay Description:Binding affinity to human EP2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >2.50E+4nMAssay Description:Binding affinity to human EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140255(CHEMBL3754085)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed