BDBM50140706 5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro[perhydrofuro[3,4-c]pyrrole-1,2''-(2'',3''-dihydro-1''H-indene)]-1'',3'',4,6-tetraone::CHEMBL27554::CHEMBL281270

SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1

InChI Key InChIKey=XWFFZCFXZJOHJE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50140706   

TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140706(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Affinity DataIC50:  850nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase, mitochondrial(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140706(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against human phenylalanyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140706(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Affinity DataIC50:  560nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140706(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human phenylalanyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140706(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase, mitochondrial(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140706(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed