BDBM50140829 4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL28098

SMILES N#Cc1c2CCCCn2c2c(ncnc12)N1CCN(CCc2ccccc2)CC1

InChI Key InChIKey=WUUUPJQNNUBMKM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50140829   

TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140829(4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-...)
Affinity DataIC50:  690nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140829(4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-...)
Affinity DataIC50:  9.63E+3nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140829(4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-...)
Affinity DataIC50:  197nMAssay Description:Inhibition of MRP1 in human H69AR cells assessed as daunorubicin accumulation preincubated for 15 mins measured after 180 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140829(4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-...)
Affinity DataIC50:  690nMAssay Description:Inhibition of MRP1 in human NCI-H69AR cells incubated for 180 mins in presence of daunorubicin by flow cytometry analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50140829(4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-...)
Affinity DataIC50:  8.19E+3nMAssay Description:Inhibition of BCRP (unknown origin) expressed in MDCK2 cells assessed as pheophorbide A accumulation preincubated for 20 mins measured after 120 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50140829(4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-...)
Affinity DataIC50:  9.63E+3nMAssay Description:Inhibition of P-gp (unknown origin) incubated for 30 mins by calcein AM analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140829(4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-...)
Affinity DataIC50:  370nMAssay Description:Inhibition of MRP1 in human H69AR cells incubated for 20 mins measured every 60 mins by calcein-AM accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed