BDBM50142895 2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-4,5-dihydro-1H-imidazole::2-phenylimidazoline::2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-fluoro-phenyl}-4,5-dihydro-1H-imidazole::CHEMBL40711::ML-253764

SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1

InChI Key InChIKey=WCPPZGPJRHLSKP-UHFFFAOYSA-N

Data  12 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50142895   

TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I125A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  151nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268F expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  160nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  160nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  160nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human wild type MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  300nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I291A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  560nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287F expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  870nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  890nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  1.82E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184L expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  2.99E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I129A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  2.71E+3nMAssay Description:Antagonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  2.86E+3nMAssay Description:Antagonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  560nMAssay Description:Antagonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  2.90E+3nMAssay Description:Antagonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  1.03E+3nMAssay Description:Antagonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  355nMAssay Description:Antagonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  6.19E+3nMAssay Description:Antagonist activity at the mutant MC4R I125L expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  708nMAssay Description:Antagonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at human MC4R expressed in CHO cells assessed as inhibition of alpha-MSH-induced cAMP production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  3.77E+3nMAssay Description:Antagonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataIC50:  103nMAssay Description:Antagonist activity at MC4R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed