BDBM50148167 4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carbonyl)benzonitrile::4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile::4-[4-(4-Methoxy-pyridin-2-ylamino)-piperidine-1-carbonyl]-benzonitrile::4-[4-[(4-Methoxypyridin-2-yl)amino]piperidine-1-carbonyl]benzonitrile, 12::CHEMBL114500

SMILES COc1ccnc(NC2CCN(CC2)C(=O)c2ccc(cc2)C#N)c1

InChI Key InChIKey=SZUVGMCKKLJAFX-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50148167   

TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50:  74nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50: >1.00E+5nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50:  6.60E+3nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50:  71nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50:  6.00E+3nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed