BDBM50149275 2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid::CHEMBL325441::[1-Benzyl-5-(4-trifluoromethoxy-phenyl)-1H-indol-3-yl]-oxo-acetic acid::[{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid

SMILES OC(=O)C(=O)c1cn(Cc2ccccc2)c2ccc(cc12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=ODXQFEWQSHNQNI-UHFFFAOYSA-N

Data  9 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50149275   

TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human plasminogen activator inhibitor-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataKd:  480nMAssay Description:Binding affinity of the compound to towards NBD-labeled S119C Plasminogen activator inhibitor-1 mutant in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity of compound towards latent Plasminogen activator inhibitor-1 expressed as apparent KdMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against Plasminogen activator inhibitor-1 by antibody assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of human non-glycosylated PAI1 using tissue type plasminogen activator substrate by direct chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  1.48E+4nMAssay Description:Inhibition of human Plasminogen activator inhibitor 1 using HRP substrate after 30 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of human glycosylated PAI1 using tissue type plasminogen activator substrate by direct chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of human glycosylated PAI1 using urokinase type plasminogen activator substrate by direct chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to human immobilized PAI1 by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of vitronectin binding to human PAI1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human PAI1 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275(2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indo...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of human non-glycosylated PAI1 using urokinase type plasminogen activator substrate by direct chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed