BDBM50151003 (S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidine-2-carbonitrile::CHEMBL1627303::CHEMBL363250::US11096924, DASH-inhibitors 9987::US11559537, Compound 9987

SMILES CC(C)(C)[C@H](N)C(=O)N1CCC[C@H]1C#N

InChI Key InChIKey=XGNBIYXILDDDQR-DTWKUNHWSA-N

Data  2 KI  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50151003   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataKi:  3.80nMAssay Description:In vitro test for inhibitory activity against human dipeptidyl peptidase IV.More data for this Ligand-Target Pair
In DepthDetails Article
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataKi:  8nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  1.90E+4nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  1.30E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50: >1.00E+8nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  7.00E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  120nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  1.20E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  42nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  19nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  1.30nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50: >1.00E+5nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  700nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50: >1.00E+5nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  4.20E+4nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against dipeptidyl-peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHomeobox protein PKNOX1(Human)
Trustees of Tufts College

US Patent
LigandPNGBDBM50151003((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Affinity DataIC50: >1.00E+8nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent