BDBM50154277 CHEMBL3774578::US10106508, Compound II-3

SMILES Cc1ccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)cc1Cl

InChI Key InChIKey=LNWBHCXDLOKRTA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50154277   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Beijing University Of Technology

Curated by ChEMBL
LigandPNGBDBM50154277(CHEMBL3774578 | US10106508, Compound II-3)
Affinity DataIC50:  163nMAssay Description:Inhibition of wildtype EGFR (unknown origin) preincubated for 30 mins followed by addition of 2x ATP-substrate mixture measured after 1 hr by Kinase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM50154277(CHEMBL3774578 | US10106508, Compound II-3)
Affinity DataIC50: <1.00E+3nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Beijing University Of Technology

Curated by ChEMBL
LigandPNGBDBM50154277(CHEMBL3774578 | US10106508, Compound II-3)
Affinity DataIC50: <200nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent