BDBM50154286 CHEMBL3774910::US10106508, Compound II-4

SMILES COc1cccc(Nc2ncnc3cc4OCC(=O)N(CCCN5CCOCC5)c4cc23)c1

InChI Key InChIKey=WOHFHMIOTRFMRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50154286   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Beijing University Of Technology

Curated by ChEMBL
LigandPNGBDBM50154286(CHEMBL3774910 | US10106508, Compound II-4)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of wildtype EGFR (unknown origin) preincubated for 30 mins followed by addition of 2x ATP-substrate mixture measured after 1 hr by Kinase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM50154286(CHEMBL3774910 | US10106508, Compound II-4)
Affinity DataIC50: <1.00E+3nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Beijing University Of Technology

Curated by ChEMBL
LigandPNGBDBM50154286(CHEMBL3774910 | US10106508, Compound II-4)
Affinity DataIC50: <200nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In DepthDetails US Patent