BDBM50154342 CHEMBL3774448

SMILES O=C1NC(=S)S\C1=C/c1ccc2ncccc2c1

InChI Key InChIKey=ZFGAUFCQRUSRCF-XFFZJAGNSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50154342   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 15 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of tetracycline-inducible EGFP-DYRK1A (unknown origin) expressed in HEK293 cells coexpressing full length human EGFP-tau protein assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  60nMAssay Description:Inhibition of full length recombinant human GST-tagged DYRK1B expressed in insect cells using KKISGRLSPIMTEQ-NH2 as substrate incubated for 15 mins i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DYRK1A catalytic domain expressed in Escherichia coli BL21(DE3) cells using KKISGRLSPIMTEQ-NH2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKCbeta (unknown origin) incubated for 15 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 17A(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  13nMAssay Description:Inhibition of STK17A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  103nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  259nMAssay Description:Inhibition of Haspin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human GST-tagged CLK1 catalytic domain (129 to 484 residues) expressed in Escherichia coli using GRSRSRSRSRSRSRSR as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  87nMAssay Description:Inhibition of recombinant human GST-tagged CLK3 expressed in baculovirus expression system by lantha screen kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  18nMAssay Description:Inhibition of full length recombinant human GST-tagged CLK4 expressed in baculovirus expression system by lantha screen kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  157nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged MLCK expressed in baculovirus expression system by lantha screen kinase binding ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DYRK2 expressed in Escherichia coli BL21(DE3) cells using KKISGRLSPIMTEQ-NH2 as substrate incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed