BDBM50154847 CHEMBL3775350::US10273244, Example 208::US10584135, Example 208

SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2c(F)cc(F)cc2F)nnc1-c1ccn(C)c(=O)c1

InChI Key InChIKey=ZRQADOCXGLFZJC-UHFFFAOYSA-N

Data  10 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50154847   

TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  3.98nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  7.59nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  7.59nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  199nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  999nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  1.20E+3nMAssay Description:Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  1.20E+3nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in baculosomes preincubated for 10 mins followed by cofactor addition measured every minute for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes preincubated for 10 mins followed by cofactor addition measured every minute for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in baculosomes preincubated for 10 mins followed by cofactor addition measured every minute for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in baculosomes preincubated for 10 mins followed by cofactor addition measured every minute for 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes preincubated for 10 mins followed by cofactor addition measured every minute for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154847(CHEMBL3775350 | US10273244, Example 208 | US105841...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in baculosomes preincubated for 10 mins followed by cofactor addition measured every minute for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed