BDBM50154891 CHEMBL3775872::US10273244, Example 25::US10584135, Example 25

SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccccc2OC(F)(F)F)n1C

InChI Key InChIKey=ZFACTJHKUXTZMC-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50154891   

TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataKi:  1.07nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataKi:  1.07nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataKi:  4.37nMAssay Description:Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataKi:  4.37nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataKi:  20.4nMAssay Description:Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataKi:  20.4nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154891(CHEMBL3775872 | US10273244, Example 25 | US1058413...)
Affinity DataIC50:  631nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed