BDBM50157605 Liarozole::Liazal::R-75251::US9963439, Liarozole

SMILES Clc1cccc(c1)C(c1ccc2[nH]cnc2c1)n1ccnc1

InChI Key InChIKey=UGFHIPBXIWJXNA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50157605   

TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  18nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  1.90E+3nMAssay Description:Eighteen compounds were tested as potential inhibitors of CYP26A1 and CYP26B1. The formation of 9-cis-4-OH-RA metabolite was monitored and the percen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  1.00E+4nMAssay Description:Compounds were assessed for inhibition (IC50, n=2) of CYP2C8, CYP2C9 and CYP3A4 in pooled human liver microsomes using selective probe substrates at ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  480nMAssay Description:Compounds were assessed for inhibition (IC50, n=2) of CYP2C8, CYP2C9 and CYP3A4 in pooled human liver microsomes using selective probe substrates at ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  1.63E+3nMAssay Description:Compounds were assessed for inhibition (IC50, n=2) of CYP2C8, CYP2C9 and CYP3A4 in pooled human liver microsomes using selective probe substrates at ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  18nMAssay Description:Eighteen compounds were tested as potential inhibitors of CYP26A1 and CYP26B1. The formation of 9-cis-4-OH-RA metabolite was monitored and the percen...More data for this Ligand-Target Pair
In DepthDetails US Patent