BDBM50158418 CHEMBL3780746

SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br

InChI Key InChIKey=XXLSGXOKOYWUNH-SRVKXCTJSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50158418   

TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  4nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  28nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataIC50:  140nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  0.460nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataIC50:  170nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed